Oklahoma Frontier Drugstore Museum & Apothecary Garden

Housed in an 1890 building in Guthrie's historic district, this free museum showcases the territory's original frontier pharmacy with artifacts like antique leech jars, asthma cigarettes, hysteria-cure ads, and elixir bottles — followed by a physic garden of medicinal herbs used by settlers and Native Americans. It's genuinely strange and legitimately fascinating.

The move: Spend an hour wandering the grim-and-quirky apothecary displays together — linger over the patent-medicine cure-all ads and compare notes on which "treatments" are most horrifying — then stroll the adjacent herb garden and try to identify the plants before reading the labels, finishing the afternoon with a walk through Guthrie's larger historic district.

• 📍 Guthrie
• 💸 $
• ⚡ Up for anything
• 🌗 Indoors

Where: 214 W. Oklahoma Ave (Gaffney Building), Guthrie, OK 73044

Hours: Mined 2026-06-07 — confirm current hours before you go.

Plan a visit & invite your people →

Proof: source 1 · source 2 · source 3

Verified 2026-06-07.